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Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium.
| Molecular Weight | 959.06 |
| Formula | C43H66N12O13 |
| CAS Number | 2855063-75-9 |
| Solubility (25°C) | Water 60 mg/mL |
| Storage | -20°C, dry, sealed |
[2] Jan Wysocki, et al. Angiotensins and the heart: is angiotensin-(1-7) cardioprotective?
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