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Andrastin A meroterpenoid compound, is a farnesyltransferase inhibitor. Andrastin A inhibits the efflux of anticancer compounds from multidrug-resistant cancer cells. Andrastin A can be isolated from Penicillium species.
| Molecular Weight | 486.6 |
| Formula | C28H38O7 |
| CAS Number | 174232-42-9 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Farnesyl Transferase Products |
|---|
| Tipifarnib
Tipifarnib (IND 58359) inhibited Farnesitransferase (FTase) with an IC50 of 0.86 nM. Tipifarnib has potential antitumor activity. Tipifarnib can inhibit exosome release of tumor cells. |
| LB42708
LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively. |
| Tipifarnib S enantiomer
Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib, Tipifarnib S enantiomer is the less active isomer. |
| L-778123 hydrochloride
L-778123 hydrochloride is a dual inhibitor of FPTase and GGptase-I with IC50 values of 2 nM and 98 nM, respectively. |
| FTI-277 hydrochloride
Fti-277 Hydrochloride, an FTase inhibitor of Farnici transferase, is a highly effective Ras CAAX peptide analog that inhibits H-RAS and K-RAS signal transduction. Fti-277 hydrochloride inhibits hepatitis delta virus (HDV) infection. |
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