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ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity.
| Molecular Weight | 504.46 |
| Formula | C27H19F3N4O3 |
| CAS Number | 450839-40-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 50 mg/mL (ultrasonic) |
| Storage | -20°C, protect from light |
| Related Farnesyl Transferase Products |
|---|
| Tipifarnib
Tipifarnib (IND 58359) inhibited Farnesitransferase (FTase) with an IC50 of 0.86 nM. Tipifarnib has potential antitumor activity. Tipifarnib can inhibit exosome release of tumor cells. |
| LB42708
LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively. |
| Tipifarnib S enantiomer
Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib, Tipifarnib S enantiomer is the less active isomer. |
| L-778123 hydrochloride
L-778123 hydrochloride is a dual inhibitor of FPTase and GGptase-I with IC50 values of 2 nM and 98 nM, respectively. |
| FTI-277 hydrochloride
Fti-277 Hydrochloride, an FTase inhibitor of Farnici transferase, is a highly effective Ras CAAX peptide analog that inhibits H-RAS and K-RAS signal transduction. Fti-277 hydrochloride inhibits hepatitis delta virus (HDV) infection. |
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