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24(S)-Hydroxycholesterol

Cat. No. M30137

All AbMole products are for research use only, cannot be used for human consumption.

24(S)-Hydroxycholesterol Structure
Synonym:

24S-OHC; 24S-HC; Cerebrosterol

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Quality Control & Documentation
Biological Activity

24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators.

Chemical Information
Molecular Weight 400.68
Formula C28H48O
CAS Number 474-73-7
Form Solid
Storage Powder -20°C
References

[1] Paola Gamba, et al. Antioxidants (Basel). The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer's Disease

[2] Yasuomi Urano, et al. Cell Death Discov. 24( S)-Hydroxycholesterol induces ER dysfunction-mediated unconventional cell death

[3] Noriko Noguchi, et al. Free Radic Biol Med. New aspects of 24(S)-hydroxycholesterol in modulating neuronal cell death

[4] Min-Yu Sun, et al. Neuroscientist. 24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival

[5] Noriko Noguchi, et al. Biochem Biophys Res Commun. Diverse functions of 24(S)-hydroxycholesterol in the brain

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Keywords: 24(S)-Hydroxycholesterol, 24S-OHC; 24S-HC; Cerebrosterol supplier, Liver X Receptor, inhibitors, activators

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