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2-D08 is a cell permeable, mechanistically unique inhibitor of protein SUMOylation. 2-D08 inhibits sumoylation by preventing transfer of SUMO from the UBC9-SUMO thioester to the substrate. 2-D08 is also an inhibitor of Axl with IC50 of 0.49 nM. 2-D08 decreases the ratio of p-Axl to t-Axl in a dose-dependent manner.
| Molecular Weight | 270.24 |
| Formula | C15H10O5 |
| CAS Number | 144707-18-6 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
| Related E1/E2/E3 Enzyme Products |
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| PYR-41
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| CC0651
CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme and inhibited the ubiquitination of p27Kip1 with IC50 value of 1.72 μM. |
| Iberdomide
Iberdomide (CC-220) is an orally effective cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC50 for cereblon binding affinity of approximately 150 nM. Iberdomide (CC-220) binds CRBN with higher affinity than lenalidomide and pomalidomide and has enhanced degradation of IKZF1 and IKZF3 with enhanced degradation. |
| Ginkgolic Acid
Ginkgolic Acid is a inhibits SUMOylation by binding E1. |
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