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PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.
Environ Int. 2024 Sep;191:108975.
BaP/BPDE suppresses homologous recombination repair in human trophoblast cells to induce miscarriage: The roles of lnc-HZ08
PYR-41 purchased from AbMole
2015 Mar.
Effects of the Ubiquitin Proteasome Inhibitor on Ion Channels in Left Ventricular Hypertrophy and Association of rs3807989 with Atrial Fibrillation
PYR-41 purchased from AbMole
 |
Source | Int J Med Sci (2018). Figure 5. PYR-41 |
| Method | Western Blotting | |
| Cell Lines | TECs | |
| Concentrations | 0.75 μg/ml | |
| Incubation Time | 24 h | |
| Results | Since RhoT1 is degraded primarily through the ubiquitin proteasome pathway, the ubiquitin-activating enzyme (E1) inhibitor PYR-41 was used to determine whether upregulation of RhoT1 could downregulate the expression of SMAD-4 and promote the expression of JAM-3. |
| Molecular Weight | 371.3 |
| Formula | C17H13N3O7 |
| CAS Number | 418805-02-4 |
| Solubility (25°C) | DMSO 38 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Marina Ikeda, et al. UBE1a Suppresses Herpes Simplex Virus-1 Replication
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