| Cat.No. | Name | Information |
|---|---|---|
| M7041 | NPPB | NPPB is a blocker of the outwardly rectifying chloride channel (ORCC) with IC50 of 80 nM. NPPB has been shown to activate the GPR35-Gαi/o and GPR35-Gα16 pathways in HEK293 cells, inducing intracellular calcium mobilization. |
| M54869 | NMD670 | NMD670 is a first-in-class small molecule inhibitor of the skeletal muscle specific chloride ion channel (ClC-1). NMD670 improves skeletal muscle function in rat models with myasthenia gravis. |
| M14209 | Picrotoxinin | Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors. |
| M14208 | Endovion | Endovion (NS3728) is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor. |
| M14207 | Chlorotoxin TFA | Chlorotoxin TFA is a peptide isolated from the venom of the scorpion Leiurus quinquestriatus, acts as a chloride channel blocker. Anti-cancer activity. |
| M11196 | R(+)-IAA-94 | R(+)-IAA-94 (R(+)-Methylindazone) is an effective chloride channel blocker. R(+)-IAA-94 inhibits Nef-sdAb19 interaction and binds to Nef. |
| M10200 | Chlorotoxin | Chlorotoxin is a 36 amino-acid peptide with anticancer activity, it is also a chloride channel blocker. |
| M9159 | Adjudin | Adjudin (also known as AF-2364) is a potent Cl- channel blocker, with a superior mitochondria-inhibitory effect. Adjudin (AF-2364) attenuates microglia activation by suppression of the NF-κB pathway. |
| M8680 | Ani9 | Ani9 is a potent and highly selective anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) inhibitor that completely inhibited ANO1 chloride current with submicromolar potency. |
| M7346 | T16Ainh-A01 | T16Ainh-A01 is a Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor. |
| M6695 | Eact | Eact is a activator of Ca 2+-activated Cl - channel transmembrane protein 16A (TMEM16A). |
| M6554 | CaCCinh-A01 | CaCCinh-A01 is a calcium-activated chloride channel (CaCC) inhibitor. |
| M4633 | Atractyloside potassium salt | Atractyloside potassium salt is a highly effective and specific inhibitor of mitochondrial ADP/ATP transport. Atractyloside potassium salt inhibited the chloride channel in rat heart mitochondrial membrane. Atractyloside potassium salt is a toxic diterpenoid glycoside, which can be isolated from the fruit of Atractyloside. |
| M56463 | NS1652 | NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC50 of 1.6 μM in human and mouse red blood cells. |
| M54413 | GaTx2 | GaTx2 is a seletive and a high affinity inhibitor of ClC-2 channels with a voltage-dependent apparent KD of ∼20 pM. |
| M39021 | Anthracene-9-carboxylic acid | Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells. |
| M28826 | T16A(inh)-C01 | T16A(inh)-C01 is an inhibitor of TMEM16A (ANO1). T16A(inh)-C01 blocks chloride channel mediated by ANO1 with an IC50 of 8.4 μM, without interfering with calcium signaling. |
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