| Cat.No. | Name | Information |
|---|---|---|
| M2255 | Genistein | Genistein is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. |
| M2199 | Camptothecin | Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells. |
| M2198 | Curcumin | Curcumin (Diferuloyl), a natural phenolic compound, is a p300/CREB binding protein specific inhibitor that inhibits histone/non-histone acetylation and histone acetyltransferase-dependent chromatin transcription. Curcumin inhibited NF-κ B and MAPKs, and had anti-inflammatory, antioxidant, anti-proliferation and anti-angiogenesis effects. Curcumin induces Nrf2 protein stabilization through Keap1 cysteine modification. |
| M2193 | Epoxomicin | Epoxomicin (BU-4061T) is a cell-permeable, selective and irreversible proteasome inhibitor with an IC50 value of 4 nM. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. |
| M2191 | Forskolin | Forskolin is a diterpenoid natural product extracted from the hairy throat sphagnum flower (Coleus forskohlii), and is also a eukaryotic adenylate cyclase (AC) activator, which can increase cAMP levels. In addition, Forskolin can be used as a substitute for Oct4 in the induction and maintenance of pluripotent stem cells in mice and promotes osteoblast differentiation in vitro with potential anti-osteoporotic activity. |
| M2121 | Nattokinase | Nattokinase is an enzyme extracted and purified from a Japanese food called nattō. |
| M2082 | Streptozotocin | Streptozotocin (STZ) is a kind of glucosamine - nitrosourea derivative. *The compound is unstable in solutions, freshly prepared is recommended |
| M2079 | Chrysin | Chrysin is a naturally occurring flavone chemically extracted from the passion flowers Passiflora caerulea. |
| M2066 | Staurosporine | Staurosporine (AM-2282) is a potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively. |
| M2053 | Wortmannin (KY 12420) | Wortmannin (KY 12420) is a specific, covalent inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) with IC50 of 3 nM. |
| M1997 | Oligomycin A | Oligomycin A is an inhibitor of mitochondrial ATP synthase and uncoupler of oxidative phosphorylation. |
| M1970 | Paclitaxel | Paclitaxel is a diterpenoid derived from the bark of the plant Picea abies, and is also a microtubule polymer stabilizer, which promotes polymerization of microtubule proteins to inhibit depolymerization, maintains the stability of microtubule proteins, and inhibits cellular mitosis, and acts on human endothelial cells with an IC50 of 0.1 pM. |
| M1831 | Cyclosporine A | Cyclosporine A (CsA，Cyclosporin A) is an immunosuppressant that binds to cyclophilin and inhibits calcineurin with an IC50 of 7 nM. Cyclosporine A [CsA] binds to the cyclophilin 18 (Cyp18)-CsA complex. the Cyp18-CsA complex recruits calcium-regulated neurophosphatase (CaN), leading to the blocking of cytokine gene transcription in activated T cells. CsA is a highly specific inhibitor of T-cell activation. |
| M1768 | Rapamycin | Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling. |
| M1753 | Trichostatin A | Trichostatin A (TSA) is a potent and specific inhibitor of mammalian histone deacetylase (HDAC) class I/II, with an IC50 value of 1.8 nM for HDAC. |
| M1575 | Lovastatin | Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). |
| M59301 | Baicalin Extract | Baicalin Extract is derived from the dried roots of Scutellaria baicalensis Georg, a plant belonging to the Lamiaceae family. It exhibits significant biological activities including antibacterial, diuretic, anti-inflammatory, cholesterol-lowering, anti-thrombotic, asthma-relieving, heat-clearing and detoxifying, and haemostatic properties. Baicalin exhibits a broad spectrum of antibacterial activity, demonstrating inhibitory effects in vitro against Shigella, Corynebacterium diphtheriae, Pseudomonas aeruginosa, Staphylococcus, Streptococcus, Streptococcus pneumoniae, and Neisseria meningitidis. |
| M59300 | Huanglian Extract | Huanglian Extract is derived from the dried rhizomes of Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao, or Coptis teeta Wall., plants belonging to the Ranunculaceae family. Huanglian Extract possesses multiple activities and effects, including antibacterial, anti-inflammatory, antioxidant, hypoglycaemic, and hypolipidemic properties. |
| M59299 | Pinelliae Extract | Pinelliae Extract is extracted from the rhizomes of Pinellia ternata (Thunb.) Breit., a plant belonging to the Araceae family. It primarily contains amino acids, β-sitosterol, pinellin, and alkaloids. Pinelliae Extract exhibits various biological activities, including central and peripheral nervous system inhibition, anti-early pregnancy effects, antiarrhythmic properties, suppression of gastric secretion in mice, antibacterial activity, and anticancer effects. |
| M59293 | Squalane | Squalane is a triacontane, one of the components of the skin's intercellular lipids. As a fully saturated hydrocarbon containing no double bonds, squalane does not undergo natural oxidation. Squalane is the lipid most closely resembling human sebum, possessing highly efficient oxygen-carrying capacity. Squalane exhibits excellent permeability, penetrating the skin to replenish cellular lipids while forming a breathable, water-permeable protective barrier on the skin's surface. |
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