ZCL278

Cat. No. M2562

All AbMole products are for research use only, cannot be used for human consumption.

Size	Price	Availability
5mg	USD 53 USD53	In stock
10mg	USD 82 USD82	In stock
50mg	USD 260 USD260	In stock
100mg	USD 390 USD390	In stock

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ZCL278 is a selective Cdc42 GTPase inhibitor with K_d of 11.4 μM.

Adv Sci (Weinh). 2022 Jul;9(21):e2201414.

Bile Acid Conjugation on Solid Nanoparticles Enhances ASBT‐Mediated Endocytosis and Chylomicron Pathway but Weakens the Transcytosis by Inducing Transport
ZCL278 purchased from AbMole
Int J Pharm. 2022 Feb 14;617:121589.

Lipid raft-mediated and upregulated coordination pathways assist transport of glycocholic acid-modified nanoparticle in a human breast cancer cell line of SK-BR-3
ZCL278 purchased from AbMole
Int J Nanomedicine. 2018 Jul 27;13:4391-4404.

Rho GTPases in A549 and Caco-2 cells dominating the endocytic pathways of nanocarbons with different morphologies.
ZCL278 purchased from AbMole
ACS Appl Mater Interfaces. 2017 Feb 22;9(7):5803-5816.

Transmembrane Pathways and Mechanisms of Rod-like Paclitaxel Nanocrystals through MDCK Polarized Monolayer
ZCL278 purchased from AbMole

	Source	International Journal of Nanomedicine (2018). Figure 5. ZCL278 (Abmole Bioscience, Houston, TX, USA)
	Method	RNA interference
	Cell Lines	A549 cells
	Concentrations
	Incubation Time	24 h
	Results	These findings indicated that Cdc42 played a vital role in the uptake of oxMWCNTs in A549 cells, while Rac1 and RhoA might not be involved in this process.

	Source	ACS Appl Mater Interfaces (2017). Figure 9. ZCL 278 (Abmole BioScience. Houston, TX, USA)
	Method	Transwells
	Cell Lines	MDCK cells
	Concentrations
	Incubation Time
	Results	As shown in Figure 9, in the presence of ZCL 278, the transmembrane amount of PTX-NCs was reduced significantly, indicating that Cdc 42 participated in the regulation of the transport of PTX-NCs.

Molecular Weight	584.89
Formula	C21H19BrClN5O4S2
CAS Number	587841-73-4
Solubility (25°C)	DMSO 70 mg/mL
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

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