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Zaprinast (M&B 22948) is an inhibitor of cGMP-selective Phosphodiesterases(PDEs). Zaprinast is a G protein-coupled receptor (GPR) 35 agonist which activates rat GPR35 strongly and activates human GPR35 moderately. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects.
| Molecular Weight | 271.27 |
| Formula | C13H13N5O2 |
| CAS Number | 37762-06-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 62.5 mg/mL (ultrasonic) |
| Storage | -20°C, protect from light, sealed |
| Related PDE Products |
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BAY-60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human). |
| Roflumilast
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Apremilast is a novel, orally available small molecule inhibitor of PDE4 with IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM. |
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