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WYC-209 is a novel inhibitor of tumor-repopulating cells (trcs), inducing trc apoptosis primarily via the caspase 3 pathway. WYC-209 induces apoptosis primarily via the caspase 3 pathway with IC50 of 0.19 μM for inmalignant murine melanoma TRCs.
In vivo, WYC-209 (0.022-0.22 mg/kg; i.v.; once every two days for 25 days) inhibits tumor metastasis in C57BL/6 mice bearing lung metastases.
| Cell Experiment | |
|---|---|
| Cell lines | A2780, A549, MCF-7, MDA-MB-435s, A375 cells |
| Preparation method | Human ovarian cancer A2780 (a), human lung cancer A549 (b), human breast cancer MCF-7 (c), human melanoma MDA-MB-435s (d), and human malignant melanoma A375 (e) were cultured in 90-Pa fibrin gels for 3 days and treated with 0.1, 1, or 10 μM WYC-209. f–j A2780, A549, MCF-7, MDA-MB-435s, and A375 were cultured in 90-Pa fibrin gels for 3 days, treated with 10 μM WYC-209, and were then washed out of the compound on day 4. |
| Concentrations | 10 μM |
| Incubation time | 24 hours |
| Animal Experiment | |
|---|---|
| Animal models | Female immune-competent C57BL/6 mice |
| Formulation | 0.1% DMSO |
| Dosages | 0.022, 0.22 mg/kg |
| Administration | intravenously injected; once every two days for 25 days |
| Molecular Weight | 368.45 |
| Formula | C20H20N2O3S |
| CAS Number | 2131803-90-0 |
| Solubility (25°C) | DMSO 70 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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| Tamibarotene
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| TTNPB
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| Fenretinide
Fenretinide (4-HPR) is a synthetic retinoid deriverative. Fenretinide is shown to exhibit binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death. |
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