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W-7 Hydrochloride is a selective calmodulin antagonist. W-7 Hydrochloride inhibits Ca2+ -calmodulin-dependent phosphodiesterase and Myosin light chain kinase. The IC50 values were 28 μM and 51 μM, respectively. W-7 Hydrochloride can induce apoptosis and has anti-cancer activity.
| Molecular Weight | 377.33 |
| Formula | C16H21ClN2O2S.HCl |
| CAS Number | 61714-27-0 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related CaMK Products |
|---|
| KN-62
KN-62 is a selective, cell permeable inhibitor of calcium/calmodulin-dependent kinase II (CaMKII; IC50 = 900 nM). |
| NH125
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor. |
| KN-92 phosphate
KN-92 is an inactive analog of the CaM kinase II inhibitor KN-93. |
| A23187
Calcimycin (A-23187) is a calcium ionophore that induces Ca2+-dependent cell death by increasing intracellular calcium concentration. |
| KN-92
KN-92 is an inactive analog of the CaM kinase II inhibitor KN-93. |
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