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Vialinin A

Cat. No. M25385

All AbMole products are for research use only, cannot be used for human consumption.

Vialinin A Structure
Synonym:

Terrestrin A

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1mg USD 220  USD220 3-4 Weeks
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Biological Activity

Vialinin A (Terrestrin A) is a potent inhibitor of ubiquitin-specific peptidases with IC50 values of 1.5, 5.9 and 22.3 μM for ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB), respectively. Vialinin A is also a potent inhibitor of TNF-α and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A (Terrestrin A) is a p-terphenyl compound with antioxidant properties. Vialinin A (Terrestrin A) can be used for autoimmune diseases and cancer research.

Chemical Information
Molecular Weight 562.57
Formula C34H26O8
CAS Number 858134-23-3
Solubility (25°C) DMSO 20 mg/mL (Need ultrasonic and warming)
Storage -20°C, dry, sealed
References

[1] Christian Bailly, et al. Molecules. Binding of Vialinin A and p-Terphenyl Derivatives to Ubiquitin-Specific Protease 4 (USP4): A Molecular Docking Study

[2] Jie Xu, et al. J Cell Mol Med. Ubiquitously specific protease 4 inhibitor-Vialinin A attenuates inflammation and fibrosis in S100-induced hepatitis mice through Rheb/mTOR signalling

[3] Himangshu Sonowal, et al. Oxid Med Cell Longev. Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization In Vitro and In Vivo

[4] Kiyoshi Okada, et al. Bioorg Med Chem Lett. Vialinin A is a ubiquitin-specific peptidase inhibitor

[5] Jun-Ichi Onose, et al. Biol Pharm Bull. Vialinin A, a novel potent inhibitor of TNF-alpha production from RBL-2H3 cells

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Keywords: Vialinin A, Terrestrin A supplier, Deubiquitinase, inhibitors, activators

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