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Upacicalcet is a calcium-sensing receptor (CaSR) agonist being developed for the study of secondary hyperparathyroidism (SHPT).
| Molecular Weight | 351.76 |
| Formula | C11H14ClN3O6S |
| CAS Number | 1333218-50-0 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Calcium-sensing Receptor Products |
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| NPS-2143
NPS-2143 is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor. |
| Strontium ranelate
Strontium ranelate, a therapeutic for osteoporosis, was thought to have a dual mode of action, simultaneously stimulating bone formation and reducing resorption. |
| Ligustroflavone
Ligustroflavone, which can be extracted from Ligustrum lucidum, is a potential calcium sensitive receptor (CaSR) antagonist. Ligustroflavone has protective effect on diabetic osteoporosis mice. |
| Cinacalcet
Cinacalcet(AMG-073) is an orally active, second-generation calcimimetic compound; AMG 073 represents a new class of compounds for the treatment of hyperparathyroidism. |
| Cinacalcet HCl
Cinacalcet Hcl (AMG-073) is an orally active, second-generation calcimimetic compound; AMG 073 represents a new class of compounds for the treatment of hyperparathyroidism. |
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