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Ubrogepant (MK-1602) is a novel oral calcitonin gene-associated peptide receptor (CGRP) antagonist with the potential to be used in acute migraine studies.
| Molecular Weight | 549.54 |
| Formula | C29H26F3N5O3 |
| CAS Number | 1374248-77-7 |
| Solubility (25°C) | DMSO ≥ 200 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] No authors listed. Expert Opin Pharmacother. Ubrogepant
[2] No authors listed. Expert Opin Pharmacother. Ubrogepant
[3] Martina Curto, et al. Expert Opin Pharmacother. Ubrogepant for the treatment of migraine
[4] David W Dodick, et al. N Engl J Med. Ubrogepant for the Treatment of Migraine
| Related CGRP Receptor Products |
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| MK-3207 hydrochloride
MK-3207 hydrochloride is a potent CGRP receptor antagonist with IC50 of 0.12 nM. |
| MK-0974
MK-0974 (Telcagepant) is a highly potent, selective and orally bioavailable CGRP receptor antagonist with Ki values of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors respectively. |
| BAR501
BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM. |
| BAR 501 impurity |
| Olcegepant (BIBN-4096)
Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide (CGRP) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP. |
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