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Tusamitamab ravtansine

Cat. No. M25054

All AbMole products are for research use only, cannot be used for human consumption.

Tusamitamab ravtansine Structure
Synonym:

SAR-408701; HuMAb2-3-SPDB-DM4

Size Price Availability Quantity
100ug USD 490  USD490 In stock
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Quality Control & Documentation
Biological Activity

Tusamitamab ravtansine (SAR-408701) is a DM4 anti-CEACAM5 antibody-drug conjugate (ADC). Tusamitamab ravtansine is composed of a humanized monoclonal antibody that binds carcinoembryonic antigen-related cell adhesion molecule-5 (CEACAM5) and a cytotoxic maytansinoid that selectively targets CEACAM5-expressing tumor cells.

Chemical Information
CAS Number 2254086-60-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Hélène Kaplon, et al. MAbs. Antibodies to watch in 2023

[2] Clemence Pouzin, et al. CPT Pharmacometrics Syst Pharmacol. Covariate analysis of tusamitamab ravtansine, a DM4 anti-CEACAM5 antibody-drυg conjugate, based on first-in-human study

[3] Clemence Pouzin, et al. J Pharmacokinet Pharmacodyn. Integrated multiple analytes and semi-mechanistic population pharmacokinetic model of tusamitamab ravtansine, a DM4 anti-CEACAM5 antibody-drυg conjugate

[4] Stéphanie Decary, et al. Clin Cancer Res. Preclinical Activity of SAR408701: A Novel Anti-CEACAM5-maytansinoid Antibody-drυg Conjugate for the Treatment of CEACAM5-positive Epithelial Tumors

Related Drug-Linker Conjugates for ADC Products
Mc-Val-Cit-PABC-PNP

Mc-Val-Cit-PABC-PNP is a histone-cleavable peptide linker for antibody-drug couplings (ADCs) that can be used for the synthesis of ADCs such as Brentuximab vedotin.

DM1-SMCC

DM1-SMCC is DM1 with a reactive linker SMCC, which can react with antibody to make ADC.

CL2A-SN-38

CL2A-SN-38 is a SN38 derivative with a peptide-linker which can easily react with antibody to form an ADC.

BS3 (bis(sulfosuccinimidyl)suberate)

BS3 (bis(sulfosuccinimidyl)suberate) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Sulfo-SMCC sodium

Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.

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Keywords: Tusamitamab ravtansine, SAR-408701; HuMAb2-3-SPDB-DM4 supplier, Drug-Linker Conjugates for ADC, inhibitors, activators

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