All AbMole products are for research use only, cannot be used for human consumption.
Tosedostat (CHR2797) is an aminopeptidase inhibitor with IC50 of 100, 150, 220, <1000, <5000, <10000 and <30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2, respectively. It has demonstrated anti-tumour activity in a number of models of cancer, both as a single agent and in synergy with cytotoxic agents such as carboplatin and paclitaxel.
| Molecular Weight | 406.47 |
| Formula | C21H30N2O6 |
| CAS Number | 238750-77-1 |
| Solubility (25°C) | DMSO 31 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Aminopeptidase Products |
|---|
| Ubenimex
Ubenimex, also known as bestatin, is a competitive protease inhibitor. |
| Acebilustat
Acebilustat is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory drug. |
| TNP-470
TNP-470 (AGM-1470; NSC 642492) is a synthetic analog of fumagillin (or Fumagillol) and a methionine aminopeptidase-2 inhibitor. |
| Bestatin hydrochloride
Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research. |
| LYS-006
LYS-006 is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) with IC50 of 2 nM. LYS-006 can be used for the research of inflammatory and autoimmune disorders, including ulcerative colitis and NASH. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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