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TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation.
| Molecular Weight | 468.54 |
| Formula | C26H32N2O6 |
| CAS Number | 921099-13-0 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Xuan Qiu, et al. Curr Eye Res. Dexamethasone increases Cdc42 expression in human TM-1 cells
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