All AbMole products are for research use only, cannot be used for human consumption.
TGFβ1-IN-1 is a potent, orally active TGF-β1 inhibitor. TGFβ1-IN-1 inhibits the upregulation of TGF-β1-induced fibrosis markers (α-SMA and fibronectin). TGFβ1-IN-1 (0-20 μM, 72 h) inhibits the proliferation of TGF-β1 (5 ng/mL)-treated LX-2 cells and inhibits LO2 cell viability with an IC50 of 105 μM.
TGFβ1-IN-1 (15 or 30 mg/kg, p.o., daily, 3weeks) prevents CCl4-induced liver injury and fibrosis, inhibits the activation of hepatic stellate cell (HSC) and epithelial-mesenchymal transition (EMT), and improves the immune microenvironment of CCl4-induced liver fibrosis as well as CCl4-induced systemic toxicity in C57BL/6J mice.
| Molecular Weight | 364.44 |
| Formula | C22H24N2O3 |
| CAS Number | 2348795-14-0 |
| Solubility (25°C) | DMSO 75 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
| Related TGF-β Receptor Products |
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LY364947 is a selective small molecule inhibitor of the TGFβ type I receptor kinase with IC50 of 59 nM. |
| LY2109761
LY2109761 is a novel TGF-β receptor type I and type II dual inhibitor, with Ki values of 38 nM and 300 nM, respectively. |
| SB-525334
SB-525334 is a potent activin receptor-like kinase (ALK5)/ type I TGFβ-receptor kinase inhibitor with IC50 of 14.3 nM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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