All AbMole products are for research use only, cannot be used for human consumption.
Tasquinimod is an oral antiangiogenic and S100A9 inhibitor. Tasquinimod allosteric binding at 10-30 nM Kd in the zinc-regulated domain of HDAC4 inhibits co-localization of N-Cor /HDAC3, thereby inhibiting deacetylation of histones and HDAC4-client transcription factors such as HIF-1α. TAMs secretes angiogenic factors such as VEGF, FGF, TNF- α and TGF-β when bone marrow is derived to inhibit cell differentiation. Tasquinimod inhibits tumor angiogenesis by inhibiting tumor invasion of S100A9/ TLR4-dependent MDSCs and/or by inhibiting HIF-1α deacetylation of HDAC4/ N-COR/HDAC3-dependent MDSCs to TAMs. Tasquinimod is an orally active quinoline-3-carboxylamide that binds with high affinity to HDAC4 and S100A9 in cancer and infiltrates host cells in the impaired tumor microenvironment, inhibiting an adaptive survival pathway required for angiogenic responses.
| Molecular Weight | 406.36 |
| Formula | C20H17F3N2O4 |
| CAS Number | 254964-60-8 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related HDAC Products |
|---|
| Belinostat
Belinostat (PXD101) is a novel HDAC inhibitor with an IC50 of 27 nM. |
| CUDC-101
CUDC-101 is a potent multitargeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively. |
| Givinostat hydrochloride monohydrate
ITF2357 (Givinostat, Gavinostat) is a histone deacetylase inhibitor. The IC50 values for maize HDAC preparations HD2, HD-1B and HD-1A are 10, 7.5 and 16 nM respectively. |
| Niltubacin
Niltubacin, as an inactive derivative of Tubacin, is a highly potent and selective, reversible cell-permeable inhibitor of HDAC6. |
| Tubacin
Tubacin (Tubulin Acetylation Inducer) is a highly potent and selective, reversible cell-permeable inhibitor of HDAC6 with IC50 of 0.004µM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
