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Substance P (6-11) is the C-terminal hexapeptideamide of Substance P. Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect.
In vivo, Substance P (6-11) (0.1-10 nM) inhibits insulin and glucagon secretion from the rat pancreas in a dose-dependent manner. By contrast, Substance P (6-11) (1-10 nM) potentiates the release of insulin, glucagon and somatostatin in the canine pancreas.
| Molecular Weight | 740.91 |
| Formula | C36H52N8O7S |
| CAS Number | 51165-07-2 |
| Storage | -20°C, sealed |
| Related Neurokinin Receptor Products |
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| Aprepitant
Aprepitant (Emend) is an antiemetic chemical compound that belongs to a class of compounds called substance P antagonists (SPA). |
| Maropitant
Maropitant (Cerenia) is a novel, selective neurokinin type-1 (NK1) receptor antagonist. |
| Eprazinone dihydrochloride
Eprazinone is a mucolytic. |
| Fosaprepitant dimeglumine salt
Fosaprepitant is a water-soluble phosphoryl procompound for Aprepitant which is a NK1 antagonist.*The compound is unstable in solutions, freshly prepared is recommended |
| Netupitant
Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity with Ki of 0.95 nM. |
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