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Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively. Streptonigrin possesses both anti-tumor and anti-bacterial activity.
| Molecular Weight | 506.46 |
| Formula | C25H22N4O8 |
| CAS Number | 3930-19-6 |
| Form | Solid |
| Storage | 2-8°C |
| Related PAD Products |
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| GSK484 hydrochloride
GSK484 hydrochloride is a potent selective reversible inhibitor of protein arginine deiminase PAD4, an enzyme believed to play a role in granulocyte and macrophage development leading to inflammation and immune response, and overexpressed in many tumors. |
| Cl-amidine hydrochloride
Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. |
| GSK199 hydrochloride
GSK199 hydrochloride is a selective PAD4 inhibitor with half-maximum inhibitory concentration (IC50) values, in the absence of calcium, of 200 nM. |
| GSK-121 Trifluoroacetate
GSK-121 Trifluoroacetate is a selective inhibitor of PAD4. |
| BB-Cl-Amidine
BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor. |
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