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SP-13786 (UAMC-1110) is a novel potent and selective inhibitor of fibroblast activation protein (fap), displaying low nanomolar inhibitory potency and high selectivity against the related dipeptidyl peptidases (dpps) dppiv, dpp9, dppii, and prolyl oligopeptidase (prep). Pharmacokinetic evaluation in mice of SP-13786 demonstrates high oral bioavailability, plasma half-life, and the potential to selectively and completely inhibit FAP in vivo.
| Molecular Weight | 344.32 |
| Formula | C17H14F2N4O2 |
| CAS Number | 1448440-52-5 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related FAP Products |
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| FAPI-4
Feiapi-4 is a fibroblast activating protein (FAP) inhibitor that can be used in cancer research. |
| Sibrotuzumab
Sibrotuzumab (BIBH 1) is a humanized IgG1 monoclonal antibody targets fibroblast activation protein (FAP). Sibrotuzumab can be used for the research of colorectal cancer and non-small cell lung cancer (NSCLC). |
| FAP-IN-2
FAP-IN-2 is a derivative of 99mTc-labeled isonitrile-containing fibroblast activation protein (FAPI) inhibitor, that can be used for tumor imaging. |
| FAP-IN-2 TFA
FAP-IN-2 TFA is a 99mTc-labeled isonitrile-containing FAP inhibitor derivative that can be used for tumor imaging. |
| FAPI-74
FAPI-74 is a PET (positron emission tomography) tracer targeting the fibroblast activation protein (FAP). |
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Products are for research use only. Not for human use. We do not sell to patients.
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