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SK1-IN-1

Cat. No. M13395

All AbMole products are for research use only, cannot be used for human consumption.

SK1-IN-1  Structure

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Quality Control & Documentation
Biological Activity

Sk1-in-1 is an effective sphingosine kinase 1 (SPHK1) inhibitor with an IC50 value of 58 nM.

Chemical Information
Molecular Weight 398.5
Formula C22H30N4O3
CAS Number 1218816-71-7
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Related SPHK Products
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K145 Hydrochloride is a selective, substrate competitive and oral inhibitor of SphK2, IC50 4.3 µM and Ki 6.4 µM. K145 hydrochloride has no activity against SphK1 and other protein kinases. K145 Hydrochloride induces apoptosis and has strong anti-tumor activity.

PF-543 HCl

PF-543 hydrochloride is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2.

MHP

MHP (Methyl caprooyl tyrosinate), an activator of sphingosine kinase (SPHK1), can significantly increase CAMP mRNA and protein levels. MHP (Methyl caprooyl Tyrosinate) can enhance anti-microbial defense and innate immunity.

MP-A08

Mp-a08 is a highly selective inhibitor of ATP-competitive sphingine kinase (SPHK1) with Ki value of 6.9 μM.

SKI-178

SKI-178 is a potent sphingosine kinase-1 (SphK1) and SphK2 inhibitor. In acute myeloid leukemia (AML) cell lines, the IC50 range is about 500 nm-1 μM. Ski-178 induces apoptosis of human acute myeloid leukemia cells in a CDK1-dependent manner.

  Catalog
Abmole Inhibitor Catalog




Keywords: SK1-IN-1 supplier, SPHK, inhibitors, activators

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