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SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway..
| Molecular Weight | 285.73 |
| Formula | C15H12ClN3O |
| CAS Number | 1807758-81-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 500 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light |
| Related Sirtuin Products |
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