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RO5166017 is an orally active and species-crosses TAAR1 agonist, with Ki values of 1.9 nM, 2.7 nM, 31 nM and 24 nM for mouse, rat, human and cynomolgus monkey, respectively.
| Molecular Weight | 219.28 |
| Formula | C12H17N3O |
| CAS Number | 1048346-74-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 25 mg/mL (ultrasonic) |
| Storage | -20°C, dry, sealed |
| Related TAAR Products |
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Tryptamine is a monoamine alkaloid and may play a role as a neuromodulator or neurotransmitter. It is an agonist of hTAAR1. It acts as a non-selective serotonin receptor agonist and serotonin-norepinephrine-dopamine releasing agent (SNDRA). Tryptamine is a selective, blood-brain-penetrating 5-HT4 receptor agonist (EC50=1-3 mM) and an endogenous ligand of the aryl hydrocarbon receptor (AHR) (Kd=10-50 nM). Tryptamine promotes intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs). |
| Ralmitaront
Ralmitaront (RO6889450), a potent and orally active partial agonist of the trace amine-associated receptor 1 (TAAR1), acts as a neuroleptic agent. Ralmitaront can be used for the research of neuro-related diseases, such as schizophrenia (SCZ), schizoaffective disorder, and negative symptoms. |
| Ulotaront HCl
Ulotaront HCl is a first-in-class, orally active, CNS-active TAAR1 agonist for studies related to schizophrenia. |
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