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Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, inhibiting apoptosis and tumor growth. VEGF-A protein is also a vasodilator that increases microvascular permeability. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer.
The recombinant mouse VEGF164 consists of 164 amino acids and has a calculated molecular mass of 19.4 kDa. A DNA sequence encoding the mouse VEGF164 (Q00731-2) (Ala27-Arg190) was expressed and purified.
Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC), the ED50 for this effect is typically 5-22 ng/mL.
Accession: Q00731-2
Apparent Molecular Weight: 22-24 kDa, reducing conditions
Endotoxin < 1 EU/µg
Lyophilized from sterile 100mM Glycine, 10mM NaCl, pH 7.0.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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