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Recombinant Human IL-11 Protein is a multifunctional cytokine produced by stromal cells such as fibroblasts, epithelial cells and osteoclasts. IL-11 is expressed in a variety of tissues, including the thymus, lung, bone, connective tissue, and central nervous system. IL-11 plays an important regulatory role in the hematopoiesis process by stimulating the growth of bone marrow, red blood cells and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits the production of pro-inflammatory cytokines, and prevents gastric mucosal damage.
Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells, the ED50 for this effect is typically 1-8 ng/mL.
The recombinant human IL-11 consists of 178 amino acids and predicts a molecular mass of 19.1 KDa. A DNA sequence encoding the mature form of human IL-11 (Pro22-Leu199) was expressed.
Accession: P20809
Endotoxin < 1 EU/µg
Apparent Molecular Weight: ~23 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Life Sci. 2023 Jul 24;330:121974.
The effect of hepatic stellate cell derived-IL-11 on hepatocyte injury in hepatic fibrosis
Recombinant Human IL-11 Protein (E. coli) purchased from AbMole
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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