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Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily. GDF-15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.
The recombinant human GDF-15 is a disulfide-linked homodimeric protein. The reduced monomer consists of 370 amino acids and has a predicted molecular mass of 40.6 kDa. A DNA sequence encoding the mature form of human GDF15 (Ala 197-Ile 308) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Immobilized Recombinant Human GFRAL Protein at 2 μg/mL (100 μL/well) can bind Recombinant Human GDF-15 Protein, the EC50 is 50-150 ng/mL.
Accession: Q99988
Apparent Molecular Weight: 44 kDa, under reducing conditions
Endotoxin < 1 EU/µg
Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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Products are for research use only. Not for human use. We do not sell to patients.
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