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Recombinant Human CYP3A4 (E.coli, N-His)

Cat. No. M11363

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human CYP3A4 (E.coli, N-His) Structure
Size Price Availability Quantity
100ug USD 440  USD440 In stock
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Quality Control & Documentation
  • Purity: >90%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

CYP3A4 is an important member of the cytochrome P45 enzyme superfamily, with 33 alleles. Human cytochrome P45 3A4 (CYP3A4) is an important drug metabolism enzyme involved in many drug-drug and food-drug interactions. Systemic inflammation is associated with inhibition of CYP3A4 activity.

Recombinant Human CYP3A4 expressed the target gene encoding Gly26-Ala503 with a His tag at the N-terminus.


Accession: P08684

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 56.8 KDa, reducing conditions

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Product Citations
Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
References

[1] Chen Sun, et al. Drug Metab Dispos. Icotinib Induces Mechanism-Based Inactivation of Recombinant Human CYP3A4/5 Possibly via Heme Destruction by Ketene Intermediate

[2] Yaoyao Cai, et al. Chem Res Toxicol. Evaluation of Recombinant CYP3A4 Variants on the Metabolism of Oxycodone In Vitro

[3] Marie Yamada, et al. J Microbiol Biotechnol. Detoxification of Aflatoxin B1 Contaminated Maize Using Human CYP3A4

[4] Bingbing Chen, et al. Chem Res Toxicol. Effects of 26 Recombinant CYP3A4 Variants on Brexpiprazole Metabolism

[5] Irina Sevrioukova. Biochemistry. Interaction of Human Drug-Metabolizing CYP3A4 with Small Inhibitory Molecules

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