Free shipping on all orders over $ 500

PF-04447943

Cat. No. M14505

All AbMole products are for research use only, cannot be used for human consumption.

PF-04447943 Structure
Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 138  USD138 In stock
25mg USD 248  USD248 In stock
50mg USD 372  USD372 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

PF-04447943 is a potent inhibitor of human recombinant PDE9A (IC50=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC50>1000 nM).

Chemical Information
Molecular Weight 395.46
CAS Number 1082744-20-4
Solubility (25°C) DMSO ≥ 54.6 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jianrong Shi, et al. Research progress of phosphodiesterase inhibitors in inflammatory bowel disease treatment

[2] Mohammad Nasiruddin Rana, et al. PDE9 Inhibitor PF-04447943 Attenuates DSS-Induced Colitis by Suppressing Oxidative Stress, Inflammation, and Regulating T-Cell Polarization

[3] Elias M Schwam, et al. A multicenter, double-blind, placebo-controlled trial of the PDE9A inhibitor, PF-04447943, in Alzheimer's disease

Related PDE Products
GSK256066

GSK256066 is a selective phosphodiesterase 4 (PDE4)inhibitor with an IC50 of 3.2 pM. *The compound is unstable in solutions, freshly prepared is recommended

BAY-60-7550

BAY-60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human).

Roflumilast

Roflumilast (APTA-2217; BYK 20869; B9302-107) is a novel and selective, long-acting inhibitor of phosphodiesterase 4 (PDE-4).

Piclamilast

Piclamilast (RP 73401) is a potent and selective inhibitor of phosphodiesterase (PDE) 4.

Apremilast

Apremilast is a novel, orally available small molecule inhibitor of PDE4 with IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM.

  Catalog
Abmole Inhibitor Catalog




Keywords: PF-04447943 supplier, PDE, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.