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PERK-IN-6 is a PERK inhibitor with an IC50 of 2.5 nM.
| Molecular Weight | 398.46 |
| Formula | C23H22N6O |
| CAS Number | 1337532-14-5 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PERK Products |
|---|
| GSK2606414
GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. |
| GSK2656157
GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM, 500-fold greater against a panel of 300 kinases. |
| Salubrinal
Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM. |
| trans-ISRIB
trans-ISRIB is a integrated stress response (ISR) inhibitor. |
| ISRIB
ISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM. |
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