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Pentostatin (Deoxycoformycin) is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Pentostatin (Deoxycoformycin) is useful for anticancer agent. Pentostatin is of limited benefit in the treatment for SR grade III-IV aGVHD.
| Molecular Weight | 268.27 |
| Formula | C11H16N4O4 |
| CAS Number | 53910-25-1 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Klohs WD, et al. Pharmacol Rev. Pentostatin: future directions.
| Related Adenosine Deaminase Products |
|---|
| Cladribine
Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively. |
| 1-Deazaadenosine
1-Deazaadenosine is a adenosine deaminase inhibitor. |
| EHNA hydrochloride
EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)). |
| ABT-702 dihydrochloride
ABT-702 dihydrochloride is a potent non-nucleoside adenosine kinase inhibitor, selective over other sites of adenosine interaction like A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase. |
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