All AbMole products are for research use only, cannot be used for human consumption.
Omecamtiv mecarbil, previously codenamed CK-1827452, is an agent that directly activates myosin, for use in the treatment of heart failure. Omecamtiv mecarbil specifically targets and activates myocardial ATPase and improves energy utilization. This enhances effective myosin cross-bridge formation and duration, while the velocity of contraction remains the same. Omecamtiv mecarbil also increases the rate of phosphate release from myosin, thereby accelerating the rate-determining step of the cross-bridge cycle, which is the transition of the actin-myosin complex from the weakly bound to the strongly bound state. Omecamtiv mecarbil could safely improve cardiac function within tolerated doses. Omecamtiv mecarbil is currently in Phase II clinical trials.
J Clin Invest. 2024 Jun 17;134(12):e177172.
Frameshift variants in C10orf71 cause dilated cardiomyopathy in human, mouse, and organoid models
Omecamtiv mecarbil purchased from AbMole
| Molecular Weight | 401.43 |
| Formula | C20H24FN5O3 |
| CAS Number | 873697-71-3 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Myosin Products |
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| (-)-Blebbistatin
(-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. *The compound is unstable in solutions, freshly prepared is recommended |
| 2,3-Butanedione monoxime
2,3-Butanedione Monoxime (BDM) is a myosin ATPASE inhibitor. 2,3-Butanedione Monoxime is a skeletal and cardiac muscle contraction inhibitor. 2,3-Butanedione monoxime induces sarcoplasmic reticulum Ca2+ release. |
| TR100
TR100 is a specific anti-tropomyosin agent that preferentially disrupts the actin cytoskeleton of tumor cells. TR100 selectively disrupts Tm5NM1/2 containing actin filaments. |
| Blebbistain
(±)-Blebbistatin (BLEB) is a small cell permeable selective myosin II inhibitor which potently relaxed normal detrusor smooth muscle. |
| Mavacamten (MYK-461)
Mavacamten, also known as SAR-439152 and MYK-461, is the first (first-class) orally bioavailable allosteric and reversible selective inhibitor of Cardiac Myosin. The IC50 of bovine heart and human heart was 490 nM and 711 nM, respectively. |
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Products are for research use only. Not for human use. We do not sell to patients.
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