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NRD167 (Et-29) is a potent and selective SIRT5 inhibitor with Ki value of 40 nM.
| Molecular Weight | 666.83 |
| Formula | C34H46N6O6S |
| CAS Number | 2166487-23-4 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage | -20°C, protect from light, sealed |
[1] Meng Li, et al. Blood Cancer Discov. Non-oncogene Addiction to SIRT5 in Acute Myeloid Leukemia
| Related Sirtuin Products |
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| Selisistat
Selisistat (EX 527) is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 98 nM. |
| SRT1720 Hydrochloride
SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway. |
| Resveratrol
Resveratrol is a phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. |
| Balsalazide disodium
Balsalazide is an anti-inflammatory compound used to study inflammatory bowel disease and ulcerative colitis. |
| Sirtinol
Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM, respectively. |
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