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Nedosiran sodium

Cat. No. M42453

All AbMole products are for research use only, cannot be used for human consumption.

Nedosiran sodium Structure

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Quality Control & Documentation
Biological Activity

Nedosiran sodium is a GalNAc-dsRNA conjugate designed to inhibit production of the hepatic lactate dehydrogenase (LDH) enzyme.

Chemical Information
CAS Number 2247026-22-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Aniruddha Amrite et al. Clin Pharmacol Drug Dev. Safety, Pharmacokinetics, and Exposure-Response Modeling of Nedosiran in Participants With Severe Chronic Kidney Disease

[2] Bernd Hoppe et al. Kidney Int. Safety, pharmacodynamics, and exposure-response modeling results from a first-in-human phase 1 study of nedosiran (PHYOX1) in primary hyperoxaluria

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GSK2837808A is a potent, selective lactate dehydrogenase A (LDHA) inhibitor with IC50s of 2.6 and 43 nM for hLDHA and hLDHB, respectively.

NHI-2

NHI-2 is an inihbitor of Lactate dehydrogenase-A (LDH-A, LDHA), a key enzyme necessary to sustain glycolysis, the major pathway used by many cancer cells for cell growth and proliferation (the Warburg effect).

AZ-33

AZ-33 (LDHA-IN-4) is a potent lactate dehydrogenase A (LDHA) inhibitor with IC50 of 0.5 μM.

GNE-140 racemate

GNE-140 racemate is a racemic mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is also a potent lactate dehydrogenase A (LDHA) inhibitor.

  Catalog
Abmole Inhibitor Catalog




Keywords: Nedosiran sodium supplier, LDH, inhibitors, activators

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