MPTP HCl

Biological Activity

MPTP hydrochloride blocked nerve-evoked twitches in a concentration (1-200 microM)-dependent manner. Allopurinol potentiated the MPTP (35 mg/kg)-induced decrease in the DOPAC+HVA/DA ratio and increase in striatal AA oxidation of the rat. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models.

Product Citations

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  Cell Mol Biol Lett. 2025 Oct 28;30(1):127.

  FGF21 confers neuroprotection in Parkinson's disease by activating the FGFR1-sirt1 pathway
  MPTP HCl purchased from AbMole

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  Inflammation. 2025 Jul 05; .

  ACE2 Alleviates Microglia Neuroinflammation by RANK-RANKL-OPG Axis in Parkinson's Disease
  MPTP HCl purchased from AbMole

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  Mol Nutr Food Res. 2025 May 13; .

  Neuroprotective Effect of Abscisic Acid on MPTP‐Induced Parkinson's Disease in Mice
  MPTP HCl purchased from AbMole

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  Mol Brain. 2025 Apr 04;18(1):29.

  Target oxidative stress-induced disulfidptosis: novel therapeutic avenues in Parkinson’s disease
  MPTP HCl purchased from AbMole

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  Curr Issues Mol Biol. 2024 Sep 12;46(9):10038-10064.

  Disulfidptosis: A New Target for Parkinson’s Disease and Cancer
  MPTP HCl purchased from AbMole

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  Patent. CN117471104A 2024 Jan 30.

  Patent. CN117471104A
  MPTP HCl purchased from AbMole

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  BMC Complement Med Ther. 2023 Jul 1;23(1):218.

  Neuroprotective effects of morroniside from Cornus officinalis sieb. Et zucc against Parkinson's disease via inhibiting oxidative stress and ferroptosis
  MPTP HCl purchased from AbMole

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  Int J Neurosci. 2022 Jul 18;1-9.

  Sinomenine exerts a neuroprotective effect on PD mouse model through inhibiting PI3K/AKT/mTOR pathway to enhance autophagy
  MPTP HCl purchased from AbMole

• 

  Patent. CN111366680B 2022 Sep 23.

  Patent. CN111366680B
  MPTP HCl purchased from AbMole

• 

  Patent. WO2021168855A1 2021 Sep 02.

  Patent. WO2021168855A1
  MPTP HCl purchased from AbMole

Chemical Information

Molecular Weight	209.72
Formula	C12H16ClN
CAS Number	23007-85-4
Solubility (25°C)	Water ≥ 55 mg/mL DMSO ≥ 5 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Sun XL, et al. J Neuroinflammation. Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models.

[2] Vernice Jackson-Lewis, et al. Nat Protoc. Protocol for the MPTP mouse model of Parkinson's disease

[3] E Bezard, et al. Neurosci Lett. Kinetics of nigral degeneration in a chronic model of MPTP-treated mice

[4] Desole MS, et al. Pharmacol Biochem Behav. Further investigation of allopurinol effects on MPTP-induced oxidative stress in the striatum and brain stem of the rat.

[5] Hsu KS, et al. Neuropharmacology. Potentiation of MPTP by 4-phenylpyridine on the neuromuscular blockade in mouse phrenic nerve-diaphragm.