All AbMole products are for research use only, cannot be used for human consumption.
Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 µM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively. It is an anthracenedione (not an anthracycline) antineoplastic agent. It disrupts DNA synthesis and DNA repair in both healthy cells and cancer cells. It is used in the treatment of certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin’s lymphoma. It was also shown to improve the survival of children suffering from first relapse of acute lymphoblastic leukaemia. It also engages in intercalation.
Nat Commun. 2025 Jan 14;16(1):617.
Oncogenic role of RARG rearrangements in acute myeloid leukemia resembling acute promyelocytic leukemia
Mitoxantrone purchased from AbMole
J Korean Med Sci. 2016 Jun;31(6): 836–842.
Silencing of ABCG2 by MicroRNA-3163 Inhibits Multidrug Resistance in Retinoblastoma Cancer Stem Cells
Mitoxantrone purchased from AbMole
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Source | J Korean Med Sci (2016). Figure 5. cisplatin, mitoxantrone and topotecan were all purchased from AbMole BioScience Inc. (Houston, USA). |
| Method | CCK8 Assay and ABCG2 ATPase assay | |
| Cell Lines | RCSC cells | |
| Concentrations | 0~10 μM | |
| Incubation Time | 72 h | |
| Results | MiR-3163 plays important roles in multidrug resistance (Table 1, Fig. 5A). Results showed that when miR-3163 was overexpressed in RCSCs, the ATPase activity of ABCG2 was significantly downregulated compared to RCSCs with Scramble (Fig. 5B). |
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Source | J Korean Med Sci (2016). Figure 4. cisplatin, mitoxantrone and topotecan were all purchased from AbMole BioScience Inc. (Houston, USA). |
| Method | CCK8 Assay and flow cytometry analysis | |
| Cell Lines | RCSC cells | |
| Concentrations | 0~10 μM | |
| Incubation Time | 72 h | |
| Results | A lower proliferation rate was observed in RCSCs transfected with miR-3163 Mimics using the CCK-8 assay (Fig. 4A).RCSCs treated with miR-3163 Mimics were more susceptible to cisplatin-induced apoptosis compared to those treated with Scramble (Fig.4B). |
| Molecular Weight | 444.48 |
| Formula | C22H28N4O6 |
| CAS Number | 65271-80-9 |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage | -20°C, protect from light |
[1] Abraham Chang. A case of mitoxantrone extravasation
[2] Mirela Enache, et al. Mitoxantrone-Surfactant Interactions: A Physicochemical Overview
[3] Benny J Evison, et al. Mitoxantrone, More than Just Another Topoisomerase II Poison
[4] F Martinelli Boneschi, et al. Mitoxantrone for multiple sclerosis
| Related Topoisomerase Products |
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Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells. |
| Dexrazoxane hydrochloride
Dexrazoxane HCl (ICRF-187, ADR-529, DXZ) is an iron chelator that can be used to prevent DOX-induced cardiotoxicity. |
| Irinotecan Hydrochloride Trihydrate
Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I. |
| Topotecan hydrochloride
Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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