All AbMole products are for research use only, cannot be used for human consumption.
MGCD0103 (Mocetinostat) is a novel HDAC inhibitor, highly specific for classes I and IV HDACs. It is well-tolerated and exhibits favorable pharmacokinetic and pharmacodynamic profiles, demonstrating target inhibition and clinical responses. MGCD0103 (Mocetinostat) has been recently shown to exhibit various effects on non-histone targets on cancer cells. The latest preclinical studies have demonstrated that MGCD0103 can induce both cell death and autophagy.
FEBS J. 2024 Sep 09.
MOF-mediated acetylation of CDK9 promotes global transcription by modulating P-TEFb complex formation
MGCD0103 purchased from AbMole
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Source | Int J Clin Exp Pathol (2015). Figure 3. MGCD0103 |
| Method | i.v. | |
| Cell Lines | liver cells | |
| Concentrations | 20, 40, 80 mg/kg | |
| Incubation Time | 7 days | |
| Results | According to the pathological changes of liver at difference dosage, MGCD0103 is hepatotoxic and its toxity is dosedependent. |
| Cell Experiment | |
|---|---|
| Cell lines | HCT116, HCT15, HT29, DU145, MDA-mb231, A549 cells line |
| Preparation method | Cell Viability Assay Cells in 96-well plates were incubated with compounds at various concentrations for 72 h at 37°C in 5% CO2. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was added at a final concentration of 0.5 mg/mL and incubated with the cells for 4 h before an equal volume of solubilization buffer [50% N,N-dimethylformamide, 20% SDS (pH 4.7)] was added. After overnight incubation, solubilized dye was quantified by reading at 570 nm using a reference at 630 nm. Absorbance values were converted to cell numbers according to a standard growth curve of the relevant cell line. The concentration which reduced cell numbers to 50% relative to DMSO-treated cells was determined as MTT IC50. |
| Concentrations | 0~100 μ M |
| Incubation time | 72 h |
| Animal Experiment | |
|---|---|
| Animal models | Female CD-1 nude mice |
| Formulation | PBS acidified with 0.1 N HCl or PEG400/0.2 N HCl saline, 40:60 |
| Dosages | daily for at least 2 weeks |
| Administration | p.o. |
| Molecular Weight | 396.44 |
| Formula | C23H20N6O |
| CAS Number | 726169-73-9 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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| Givinostat hydrochloride monohydrate
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Products are for research use only. Not for human use. We do not sell to patients.
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