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Metformin (1, 1-dimethylbiguanide) inhibits mitochondrial respiratory chains in the liver, leads to AMPK activation and enhances insulin sensitivity, and can be used in type 2 diabetes research. Metformin can cross the blood-brain barrier and induce autophagy, and Metformin is a CD47 inhibitor in vitro.
Inflamm Res. 2023 Dec 13.
The immunomodulatory effects of metformin in LPS-induced macrophages: an in vitro study
Metformin purchased from AbMole
| Molecular Weight | 129.17 |
| Formula | C4H11N5 |
| CAS Number | 657-24-9 |
| Solubility (25°C) | DMSO 60 mg/mL Water 30 mg/mL |
| Storage | -20°C, sealed, protect from light |
[1] Ziquan Lv, et al. Metformin and Its Benefits for Various Diseases
[2] Monika Podhorecka, et al. Metformin - its potential anti-cancer and anti-aging effects
[3] Laura J McCreight, et al. Metformin and the gastrointestinal tract
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