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Mdl-800 is a selective allosteric activator of SIRT6, a member of the SIRT deacetylase family responsible for deacetylation of histone H3K9Ac and H3K56ac, with tumor suppressive activity. Mdl-800 increased SIRT6 deacetylase activity by up to 22 times, leading to cell cycle arrest and inhibiting its proliferation. It also inhibited the growth of hepatocellular carcinoma line BEL7405 xenograft.
Int J Biol Macromol. 2025 Sep 02; .
Delactylation of H3K9 by Sirtuin6 inhibits MGMT transcription and reverses temozolomide resistance in glioblastoma
MDL-800 purchased from AbMole
| Molecular Weight | 626.3 |
| Formula | C21H16BrCl2FN2O6S2 |
| CAS Number | 2275619-53-7 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL |
| Storage | 2-8°C |
| Related Sirtuin Products |
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| Selisistat
Selisistat (EX 527) is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 98 nM. |
| SRT1720 Hydrochloride
SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway. |
| Resveratrol
Resveratrol is a phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. |
| Balsalazide disodium
Balsalazide is an anti-inflammatory compound used to study inflammatory bowel disease and ulcerative colitis. |
| Sirtinol
Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM, respectively. |
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Products are for research use only. Not for human use. We do not sell to patients.
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