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MC1568 is a selective inhibitor of class IIa histone deacetylases (HDACs). In vivo, MC1568 shows an apparent tissue-selective HDAC inhibition. In skeletal muscle and heart, MC1568 inhibits the activity of HDAC4 and HDAC5 without affecting HDAC3 activity, thereby leaving MEF2-HDAC complexes in a repressed state. In F9 cells, MC1568 specifically blocks endodermal differentiation despite not affecting retinoic acid-induced maturation of promyelocytic NB4 cells. In 3T3-L1 cells, MC1568 attenuates PPARγ-induced adipogenesis. Finally, treatment of pancreatic explants with the selective class IIa HDAC inhibitor MC1568 enhances expression of Pax4, a key factor required for proper β-and δ-cell differentiation and amplifies endocrine β- and δ-cells.
Front Physiol. 2025 Apr 08;16:1520246.
Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment
MC1568 purchased from AbMole
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Source | Toxicol Sci (2016). Figure 1. MC1568 |
| Method | Cell Viability | |
| Cell Lines | SH-SY5Y cells | |
| Concentrations | 5 μM | |
| Incubation Time | 24h | |
| Results | Interestingly, cell viability was significantly ameliorated when cells were pretreated with MC1568, but not with MS275 compared with cells exposed to thimerosal alone |
| Molecular Weight | 314.31 |
| Formula | C17H15FN2O3 |
| CAS Number | 852475-26-4 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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