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Lotilaner

Cat. No. M40537

All AbMole products are for research use only, cannot be used for human consumption.

Lotilaner Structure
Size Price Availability Quantity
1mg USD 40  USD40 In stock
5mg USD 90  USD90 In stock
10mg USD 150  USD150 In stock
25mg USD 360  USD360 In stock
50mg USD 560  USD560 In stock
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Quality Control & Documentation
Biological Activity

Lotilaner is a gamma-aminobutyric acid (GABA)-gated chloride channel inhibitor that is highly selective against mites. It has antiparasitic activity with an IC50 value of 23.84 nM against the Drosophila GABA receptor and can be used in studies related to helminth mite blepharitis.

Chemical Information
Molecular Weight 596.76
Formula C20H14Cl3F6N3O3S
CAS Number 1369852-71-0
Form Solid
Solubility (25°C) DMSO >100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yahiya Y Syed. Drugs. Lotilaner Ophthalmic Solution 0.25%: First Approval

[2] Ian Benjamin Gaddie et al. Ophthalmology. Lotilaner Ophthalmic Solution 0.25% for Demodex Blepharitis: Randomized, Vehicle-Controlled, Multicenter, Phase 3 Trial (Saturn-2)

[3] Elizabeth Yeu et al. Cornea. Lotilaner Ophthalmic Solution, 0.25%, for the Treatment of Demodex Blepharitis: Results of a Prospective, Randomized, Vehicle-Controlled, Double-Masked, Pivotal Trial (Saturn-1)

[4] Susan E Little. Parasit Vectors. Lotilaner - a novel systemic tick and flea control product for dogs

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Keywords: Lotilaner supplier, Parasite, inhibitors, activators

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