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Lifitegrast sodium

Cat. No. M45151

All AbMole products are for research use only, cannot be used for human consumption.

Lifitegrast sodium Structure
Synonym:

SAR 1118 sodium; SHP-606 sodium

Size Price Availability Quantity
10mg USD 66  USD66 In stock
50mg USD 200  USD200 In stock
100mg USD 330  USD330 In stock
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Quality Control & Documentation
Biological Activity

Lifitegrast sodium is a potent integrin antagonist that blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen (LFA-1) and interrupts the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits the attachment of Jurkat T cells to ICAM-1 with an IC50 of 2.98 nM.May be useful in studies related to dry eye.

Chemical Information
Molecular Weight 637.46
Formula C29H23Cl2N2NaO7S
CAS Number 1119276-80-0
Form Solid
Solubility (25°C) Water 100 mg/mL
DMSO 100 mg/mL
Storage 4°C, dry, sealed
References

[1] Zixuan Wang, et al. Front Biosci (Landmark Ed). An animal study on the effect of topically administered ambroxol for dry eye

[2] Christopher J Day, et al. mBio. Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2-ACE2 Receptor Interactions

[3] Daniel A Hussar, et al. J Am Pharm Assoc (2003). Lifitegrast, Bezlotoxumab, and Sugammadex sodium

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Keywords: Lifitegrast sodium, SAR 1118 sodium; SHP-606 sodium supplier, Integrin, inhibitors, activators

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