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Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. SGLT2 selective inhibitor ipragliflozin exerts a beneficial effect on glycaemic control and ameliorates diabetes-associated metabolic abnormalities and complications in STZ-induced diabetic rats, and would be a potential agent for the treatment of type 1 diabetes.
| Cell Experiment | |
|---|---|
| Cell lines | MCF-7 human breast cancer cell lines |
| Preparation method | Cell proliferation assays Briefly, cells were seeded in 12-well tissue culture plates and maintained in complete medium with 0-50 μM ipragliflozin. Cell proliferation was analyzed 0-4 days later by cell counting using a hemocytometer. |
| Concentrations | 1, 10, 50 μM |
| Incubation time | 24, 48, 72, 96 hours |
| Animal Experiment | |
|---|---|
| Animal models | Male C57BL/6J wild-type (WT) mice, Male C57BL/6J-ob/ob (ob/ob) mice |
| Formulation | DMSO |
| Dosages | 10 mg/kg/day |
| Administration | Oral gavage |
| Molecular Weight | 404.45 |
| Formula | C21H21FO5S |
| CAS Number | 761423-87-4 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related SGLT Products |
|---|
| Dapagliflozin
Dapagliflozin (BMS-512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2). |
| Canagliflozin
Canagliflozin is a potent, selective sodium glucose co-transporter 2 inhibitor. |
| Empagliflozin
Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. |
| Phloridzin
Phloridzin is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor. |
| Phloretin
Phloretin (NSC 407292; RJC 02792) is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). |
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