HEPES

Biological Activity

HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is a multi purpose buffer used in biological research.

Product Citations

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  Nucleic Acids Res. 2022 Aug 12;50(14):7938-7958.

  HDAC1 and PRC2 mediate combinatorial control in SPI1/PU.1-dependent gene repression in murine erythroleukaemia
  HEPES purchased from AbMole

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  Acta Pharm Sin B. 2022 Aug.

  Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1highCD11b+ cells elimination in hepatocellular carcinoma
  HEPES purchased from AbMole

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  Cell Commun Signal. 2022 Jul 7;20(1):102.

  Circular dorsal ruffles disturb the growth factor-induced PI3K-AKT pathway in hepatocellular carcinoma Hep3B cells
  HEPES purchased from AbMole

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  Nat Commun. 2021 Jun 23;12(1):3896.

  Single cell derived mRNA signals across human kidney tumors
  HEPES purchased from AbMole

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  EMBO Mol Med. 2021 Jul 7;13(7):e13067.

  Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis
  HEPES purchased from AbMole

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  Adv Healthc Mater. 2021 Aug;10(16):e2100821.

  Extracellular Matrix Stiffness Regulates DNA Methylation by PKCα-Dependent Nuclear Transport of DNMT3L
  HEPES purchased from AbMole

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  Cell Death Dis. 2021 Feb 15;12(2):179.

  Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors
  HEPES purchased from AbMole

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  Cells. 2021 Feb 18;10(2):430.

  Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis
  HEPES purchased from AbMole

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  Cell Stem Cell. 2020 Nov 5;27(5):840-851.e6.

  Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo
  HEPES purchased from AbMole

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  Nat Commun. 2020 Aug 27;11(1):4279.

  Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer
  HEPES purchased from AbMole

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  Environ Health Perspect. 2020 Jun;128(6):67008.

  Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation
  HEPES purchased from AbMole

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  Sci Rep. 2020 Jul 31;10(1):12991.

  Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis
  HEPES purchased from AbMole

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  J Virol. 2020 Feb 14;94(5):e01791-19.

  Targeting Kaposi's Sarcoma-Associated Herpesvirus ORF21 Tyrosine Kinase and Viral Lytic Reactivation by Tyrosine Kinase Inhibitors Approved for Clinical Use
  HEPES purchased from AbMole

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  NAS. 2020 Jun.

  Multiscale activity imaging in mammary gland reveals how oxytocin enables lactation
  HEPES purchased from AbMole

Chemical Information

Molecular Weight	238.3
Formula	C8H18N2O4S
CAS Number	7365-45-9
Solubility (25°C)	Water ≥ 200 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Pierce, et al. J Med Chem. Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase.