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GsMTx4 is a spider venom peptide that selectively inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 significantly attenuates bladder hyperactivity.
Adv Healthc Mater. 2025 Jun 26; .
CXCR4 Clustering Induced by Polymeric Nanothreads Impedes Cancer Cell Metastasis via PIEZO1‐Mediated Mechanotransduction
GsMTx4 purchased from AbMole
Bone Res. 2024 Mar 29;12(1):20.
Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx
GsMTx4 purchased from AbMole
Front Immunol. 2023 May 16;14:1194662.
Macrophages induce gingival destruction via Piezo1-mediated MMPs-degrading collagens in periodontitis
GsMTx4 purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | 4T1 cells |
| Preparation method | To determine the impact of mechanical forces on the PIEZO1 channel in cells, the cells were either left untreated or subjected to one of the following treatments: i) P-BS-CM1 for 2 h, followed by P-CM2 for an additional 2 h; or ii) P-BS-CM1 and GsMTx4 (PIEZO1 channel inhibitor) for 2 h, followed by P-CM2 and GsMTx4 for an additional 2 h (at a concentration equivalent to 1 mg mL−1 BS, with CM1 and CM2 in a 1:1 molar ratio, and GsMTx4 at 2.5 µm). |
| Concentrations | 2.5 μM |
| Incubation time | 4 h |
| Animal Experiment | |
|---|---|
| Animal models | Female Sprague Dawley (SD) rats |
| Formulation | ddH2O |
| Dosages | 5 μl/Rat (8 μM) |
| Administration | Spinal injection at a rate of 1 μL/min |
| Molecular Weight | 4101.89 |
| Formula | C185H279N49O45S6 |
| CAS Number | 1209500-46-8 |
| Solubility (25°C) | Water 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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