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GSK-A1 

Cat. No. M28374

All AbMole products are for research use only, cannot be used for human consumption.

GSK-A1  Structure
Size Price Availability Quantity
1mg USD 90  USD90 In stock
5mg USD 147  USD147 In stock
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Quality Control & Documentation
Biological Activity

GSK-A1 is a selective type III phosphatidylinositol 4-kinase PI4KA (PI4KIIIα) inhibitor with a pIC50 of 8.5-9.8. GSK-A1 inhibits PtdIns(4,5)P2 resynthesis with an IC50 of about 3 nM. GSK-A1 potently decreases the levels of PtdIns(4)P with a negligible effect on PtdIns(4,5)P2. GSK-A1 has the potential for anti-hepatitis C virus (HCV) research.

Chemical Information
Molecular Weight 574.63
Formula C29H27FN6O4S
CAS Number 1416334-69-4
Form Solid
Storage Powder -20°C
References

[1] Larissa Smulders, et al. Biomolecules. Phosphatidylinositol Monophosphates Regulate the Membrane Localization of HSPA1A, a Stress-Inducible 70-kDa Heat Shock Protein

[2] Marek Kučka, et al. Front Endocrinol (Lausanne). Calcium-Prolactin Secretion Coupling in Rat Pituitary Lactotrophs Is Controlled by PI4-Kinase Alpha

[3] Gillian L Dornan, et al. J Mol Biol. Probing the Architecture, Dynamics, and Inhibition of the PI4KIIIα/TTC7/FAM126 Complex

[4] S J Beebe, et al. J Biol Chem. Purification and characterization of a cAMP- and Ca2+-calmodulin-independent glycogen synthase kinase from porcine renal cortex

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  Catalog
Abmole Inhibitor Catalog




Keywords: GSK-A1  supplier, PI3K, inhibitors, activators

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