All AbMole products are for research use only, cannot be used for human consumption.
GS-9973 is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM, which is currently undergoing clinical evaluation for autoimmune and oncology indications.
| Molecular Weight | 411.46 |
| Formula | C23H21N7O |
| CAS Number | 1229208-44-9 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Anjali Cremer, et al. Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia
[3] Chen Qu, et al. Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis
| Related Syk Products |
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| R-406
R406 is an orally bioavailable and selective inhibitor of spleen tyrosine kinase (Syk) with the IC50 of 41nM and Ki value of 30 nM. |
| Fostamatinib disodium
Fostamatinib disodium (R788, R-935788) is a potent, ATP-competitive and selective Syk (Spleen tyrosine kinase) inhibitor with IC50 of 41 nM. |
| Fostamatinib
Fostamatinib (R788) is a spleen tyrosine kinase (Syk) inhibitor with IC50 of 41 nM. |
| P505-15 hydrochloride
P505-15 (PRT062607) is a novel, highly selective inhibitor of Syk with IC50 value of 1-2 nM. |
| Piceatannol
Piceatannol, a natural stilbene, is a selective Syk inhibitor and ~10-fold selectivity versus Lyn. |
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