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Gramicidin S is a cyclic peptide antibiotic produced by Bacillus brevis var. Gause-Brazhnikova. Gramicidin S exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S also inhibits ion channels, with IC50s of 41 μM, 24 μM, and 3 μM for Na+/K+-ATPase, tobacco leaf plasma membrane Mg2+/K+-ATPase, and rat heart plasma membrane Ca2+-ATPase, respectively.
Microb Cell Fact. 2025 Sep 02;24(1):199.
Identification of novel Gramicidin S analogs from Aneurinibacillus aneurinilyticus isolated from corn steep liquor with potential antifungal activity
Gramicidin S purchased from AbMole
ACS Omega. 2024 Jan 30;9(6):6873-6879.
A Novel Method for Creating Heterologous Lethal Antibiotic Producers by Screening from Combi-OGAB Library with Various Promoters in a Biosynthetic Gene Cluster
Gramicidin S purchased from AbMole
| Molecular Weight | 1141.45 |
| Formula | C60H92N12O10 |
| CAS Number | 113-73-5 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage | -20°C, dry, sealed |
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